Yes, many users have successfully used Otterbox cases in conjunction with tempered glass screen protectors. However, it is important to ensure that the screen protector is compatible with the specific Otterbox case model being used. Some thicker screen protectors may not fit well with certain Otterbox cases, potentially leading to issues such as lifting at the edges or bubbles beneath the protector. Otterbox designs its cases with screen protection in mind, so users should verify that the combination of the case and screen protector does not obstruct functionality, such as responsiveness to touch or facial recognition features. For the best experience, it is advisable to check the product specifications on the Otterbox website for any recommendations or potential compatibility concerns.