To update your contact information with 23andMe, you will need to access your account on their website. After logging in, navigate to the account settings or profile section. There, you should find options to edit your personal information, including your email address, phone number, and mailing address. Make sure to save any changes you make to ensure that your updated contact information is reflected in their system. It is also advisable to verify your new email address through a confirmation link that 23andMe may send you. If you encounter any difficulties, you may want to check the help section on the 23andMe website for further guidance or consult their FAQ for more details on managing your account.