Yes, Tempur-Pedic mattresses are generally compatible with adjustable bed frames. In fact, one of the advantages of Tempur-Pedic mattresses is their ability to conform to various bed bases, including those that are adjustable. These mattresses are designed with flexibility in mind, allowing them to move smoothly with the frame as it changes positions. This adaptability enhances the overall sleeping experience by providing tailored support and comfort in different reclining positions. It is important, however, to ensure that the specific adjustable bed frame you choose is compatible with the selected Tempur-Pedic mattress model. If you would like more detailed compatibility information or product recommendations, visiting the official Tempur-Pedic website may provide additional resources and guidance.