Yes, you can use different drive capacities in a Drobo device. Drobo technology is designed to take advantage of heterogeneous drive sizes, meaning that it can accommodate drives of varying capacities seamlessly. This feature allows users to mix and match drives according to their needs, which may optimize both performance and storage efficiency. When you install drives of different sizes, Drobo's BeyondRAID technology will intelligently manage how data is distributed across these drives for redundancy and optimization. However, it is important to note that the total usable capacity of the Drobo will be limited by the size of the smallest drive. For example, if you use a combination of drives with different capacities, the available storage will be equivalent to the total space of all drives minus the space taken up for redundancy. For further details tailored to specific Drobo models, visiting their official website may provide additional insights.