The Thundershirt is designed to be a safe and comfortable solution for pets experiencing anxiety or stress. Generally, pets can wear the Thundershirt for extended periods, especially during situations that typically trigger anxiety, such as thunderstorms, fireworks, or travel. It is advisable to initially introduce the Thundershirt in short sessions to allow your pet to acclimate to wearing it. After your pet seems comfortable, it can be worn for several hours at a time. However, it is important to monitor your pet's behavior and comfort level throughout this time. If at any point your pet shows signs of distress or discomfort, it is best to remove the shirt. For the most comprehensive guidance, checking the product information on the Thundershirt website may provide additional insights specific to individual pets and their needs.