Returning an item to Office Depot without the original packaging can be a bit challenging, but it is not impossible. Generally, Office Depot encourages customers to return items in their original packaging whenever possible, as this helps to ensure that the product is returned in sellable condition. However, if the item is defective or damaged, Office Depot may still accept the return even without the original packaging. It is important to keep in mind that the store's return policy may vary based on the type of item and the reason for the return. To clarify specific policies regarding returns without original packaging, customers can check the comprehensive return policy on the Office Depot website. This will provide guidance on the necessary steps to take and any potential restrictions.